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Nunn, E., et al., Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism

The ADA 2026 Standards of Care now recommend GLP-1 receptor agonists with demonstrated cardiovascular benefit for patients with type 2 diabetes and established ASCVD, multiple cardiovascular risk factors, or chronic kidney disease, and note that combination with SGLT2 inhibitors may provide additive benefit

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Prevention strategies include eating frequent small meals rather than large ones, limiting dietary fat to 30-40 grams per day during rapid weight loss, staying hydrated, and maintaining some physical activity