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Islets express nearly 300 GPCRs [10] and GPCRs represent 35% of all current drug targets [11]
Hartwell EE, Jinwala Z, Milone J, Ramirez S, Gelernter J, Kranzler HR, et al
10.1345/aph.1P714 53 LeeP
The GLP-1 drug participants had no progression of motor symptoms (-0.04), and the 3.04 worsening in the placebo group (difference between the two arms=3.08) is just short of what is considered clinically meaningful (3.5)
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