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In lean cynomolgus monkeys, MEDI4166 demonstrated robust PCSK9 suppression and LDL-C reduction
According to the FDA, the agency has received reports of gastroparesis with semaglutide and liraglutide, some of which documented the adverse event as not recovered after discontinuation of the respective product at the time of the report. The FDA statement qualified the report by clarifying that gastroparesis can be a complication of diabetes
Most patients distinguish between the two: decreased hunger persists, while nausea fades
While it's slightly less effective at lowering blood sugar alone than Metformin, it works well in combination
