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Disruption of the BBB including compromised BBB integrity and subsequent leakage of plasma constituents into the brain parenchyma, and impaired BBB dysfunction consisting of compromised transport system, reduced CBF, and heightened vascular inflammatory response at the BBB level, which are closely interlinked with the accumulation of A and the presence of neurofibrillary tangles [137]

For instance, women with diabetes may experience fatigue due to fluctuating blood sugar levels, while those with heart disease may find that their stamina is significantly reduced

Clin Chim Acta 152:135, 1985