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SGLT2-i Initiation and Insulin De-Escalation In a retrospective cohort study by Champion et al., initiation of SGLT2-ioften in combination with metformin and/or a GLP-1 receptor agonistled to significant reductions in both insulin dose and overbasalization rates
& Lehner, B
On one hand, patients achieve significant health benefits by reducing their body mass index (BMI)
Others may develop gradually over the first week as the medication begins affecting appetite, digestion, and fullness signals
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