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For RCTs, this included assessment of: (1) risk of bias (via Cochrane RoB 2 tool), (2) inconsistency of results across studies, (3) indirectness of evidence, (4) imprecision due to sample size or confidence intervals, and (5) potential publication bias
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202,203,204,205,206,207,208,209 Utilizing data from observational epidemiologic studies in conjunction with experimental evidence from in vitro and animal model investigations, elevated serum urate levels have been suggested as being potentially linked to concurrent metabolic disorders
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