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Your healthcare provider can assess whether concurrent use is appropriate for your individual circumstances and establish a suitable monitoring plan

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7,77 Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in which one or more of the following occur due to the loss of proper regulation by the kidneys: Abnormal bone mineralization, strength, growth, and turnover Calcification of non-bone tissues, including blood vessels Irregularities in vitamin D, calcium, phosphorus, fibroblast growth factor-23, and parathyroid hormone metabolism Each of these abnormalities is associated with a high risk of mortality, primarily attributable to the cardiovascular consequences

Future Research Needed to Optimize Treatment Strategies The authors acknowledged several limitations of their study, including that trial durations of 48 to 72 weeks are too short to assess whether histologic gains translate into reduced rates of cirrhosis or mortality over the long term