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In severe cases, it can cause severe altitude sickness such as HAPE and HACE ( Under acute hypobaric hypoxia, the body adapts to the external environment by changing a series of gene expressions, and hypoxia inducible factor-1 (HIF-1) is the most important transcription factor that regulates cellular adaptation to hypoxia, which plays a key role in cellular perception and acclimatation to the change of oxygen concentration ( With its multi-compounds and multi-target properties, traditional Chinese medicine (TCM) has been widely used as an alternative medical treatment for various diseases ( 2 Methods Literature searches were conducted through Scopus, Web of Science, PubMed, and China National Knowledge Infrastructure databases using the terms traditional Chinese medicine, herbal medicine, acute mountain sickness, high-altitude pulmonary edema, high-altitude cerebral edema, acute hypobaric hypoxia, and high-altitude, as well as various combinations of these keywords
They are the architecture that makes the clinical outcomes possible
Taxifolin (dihydroquercetin): shows promise in reducing inflammatory responses and acute flare frequency, particularly when combined with dietary interventions (Piao et al., 2022)
Cancer-associated fibroblast-derived lumican promotes gastric cancer progression Via the integrin B1-fak signaling pathway
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