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Recent research has shown that GIP helps reduce oxidative stress in human endothelial cells and prevents the release of inflammatory cytokines in visceral adipose tissue [59]

There is also a need to develop standardized protocols for assessing NP biodistribution and therapeutic outcomes in clinical trials [156]

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Given that NRF2 regulates the expression of numerous genes associated with oxidative stress and inflammation, the application of omics methodologies, which allow for the simultaneous measurement of hundreds to thousands of molecular targets, may help to fully delineate how NRF2 activity influences the complex interplay between redox homeostasis and sleep regulation