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Dose escalation schedule directly affects the timeline to therapeutic effect

On average, individuals stay on semaglutide for at least 6 months to a year to achieve their weight loss goals, though some may continue longer for maintenance, especially if results plateau or weight is regained when stopping

These strategic substitutions collectively contribute to improved stability and extended half-life compared to native GHRH while maintaining the natural pulsatile release pattern characteristic of endogenous growth hormone regulation