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A useful way to frame the difference: tretinoin is a top-down instruction that reprograms the epidermis, whereas GHK-Cu is a bottom-up supply of signal and cofactor that helps the dermis rebuild
The concentrations and dose ranges differ
Blood pressure improvements were observed across prespecified subgroups including participants with and without baseline hypertension
Although the mortality rate and disability-adjusted life years showed a decreasing trend from 1990 to 2021, the incidence and prevalence continue to rise due to population growth and aging, and the ASIR is projected to increase to 0.57 per 100,000 population by 2050 (Liu et al., 2025)
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