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While both methods aim to increase your B12 levels, they operate on very different timelines and through different biological pathways
Higher NAD+ activates the sirtuin family of NAD+-dependent deacetylases, particularly SIRT1, which deacetylates PGC-1alpha (promoting mitochondrial biogenesis), FOXO transcription factors (enhancing stress resistance), and NF-kappaB (reducing inflammation)
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Check the official Drugs@FDA database and the FDA's drug approval resources for current information
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