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the clinical relevance of this finding in humans is unknown, and in UK and EU prescribing information this is noted as a precaution rather than a formal contraindication but individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss this with their doctor
This is a major differentiator from full HGH, which can worsen insulin resistance at therapeutic doses
Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
doi:10.3389/fneur.2014.00227
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