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Those with evidence of central obesity and elevated waist circumference may particularly benefit given the metabolic risks associated with visceral fat accumulation, though this is not an FDA-labeled selection criterion

PubMed laboratory research record [PMID: 34430539] PubMed record related to this compound for laboratory literature review

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Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]