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Instead of acting locally on the skin, its introduced systemically, usually in small doses injected under the skin

Targeting HSPs in autoimmune diseases HSP90 inhibition and inflammatory control HSP90 inhibitors have shown notable immunomodulatory activity in preclinical autoimmune models, consistent with the role of HSP90 in stabilizing signaling proteins that amplify immune activation

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Coenzyme Q10 (CoQ10), which supports mitochondrial health and indirectly stabilizes telomere length through reduced oxidative stress