The published Phase II trials demonstrated 2.6kg mean fat mass reduction over 12 weeks at 1mg daily subcutaneous dosing in obese subjects maintaining eucaloric intake
This is the practical reason a reader who is nervous about small-volume accuracy might prefer the 50 mg protocol the trade-off being that each vial carries fewer total doses, as the supply math shows next

Reasons for fatigue Fatigue stems from physical or mental factors, including things like: Metabolic conditions such as diabetes, kidney disease, Cushing syndrome, and thyroid conditions Mental health issues such as depression, stress, eating disorders, anxiety, and burnout Cardiovascular conditions affecting blood flow, such as arrhythmias, heart disease, and heart failure Medications such as antidepressants, antihistamines, steroids, statins, and sedatives Sleep problems due to insomnia, narcolepsy, jet lag, and sleep apnea Chemical imbalances due to too little or too much of various essential nutrients, vitamins, and minerals Facts about B12 deficiency Also referred to as cobalamin deficiency and named after the scientific term for this water-soluble nutrient, a B12 deficiency can result from low dietary intake or from your body not absorbing the vitamin properly
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