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With regard to POMC gene regulation, it has been reported that the POMC promoter contains forkhead DNA-binding sites adjacent to distal site, and FoxO1 competes with STAT3 for binding to neighboring DNA sequences in the POMC promoter, thereby inhibiting leptin-mediated POMC expression [70]

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A major change to her prescription benefits meant the medication she was using to manage her weight a treatment that had taken years of trial and error to get right would no longer be covered by insurance