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DSIP is studied in sleep-wake and stress-response pathway models

Elevated levels of cholesterol carried by apolipoprotein B (apoB) (non-high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein-C [LDL-C]) is a root cause of atherosclerosis and reducing levels of atherogenic cholesterol lowers atherosclerotic cardiovascular disease (ASCVD) risk [12]

The ORF9b could further manipulate host mitochondria by releasing mitochondrial DNA (mt-DNA) into the cytoplasm to activate mt-DNA-induced inflammasome and suppress innate as well as adaptive immunity 162

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