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This is the shared mechanistic theme across the copper-peptide family, with GHK-Cu the most-characterized example (Pickart & Margolina 2018, PMID 29986520)

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[Article] [PubMed]77

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In addition, metreleptin requires daily injection, which is painful in lipodystrophic individuals due to the paucity of subcutaneous adipose tissue, is costly and not available to patients in all countries

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