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A conservative approach using 0.25 mg daily for the first two weeks allows assessment of individual response before considering increases
In short, while vigilance and longer follow-up are prudent, current high-quality data suggest that for most patients the metabolic and cardiovascular benefits probably outweigh the very low absolute risksparticularly when therapy is combined with lifestyle support and appropriate monitoring
Can cause electrolyte imbalances with daily use
Most GI effects are mild to moderate and often diminish over weeks to months as the body adapts to the medication
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