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Deletion of hepatocyte-specific DPP4 in these aged mice did not affect glucose tolerance as only whole-body deletion of DPP4 increased systemic active GLP-1 and led to reduced blood glucose excursion during oral glucose tolerance test (Supplemental Figure 3, A and B), consistent with previous work (22, 23)
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Indeed, Raufman had isolated two peptides (exendin-1 and exendin-2) from Gila saliva with unknown function ( [22] ) ( [80] )
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