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In preclinical studies, telaglenastat (CB-839), a Gln synthetase inhibitor, promoted the function of CD4 + Th 1 cells and CD8 + T cells, and inhibited the function of Th 17 cells

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In contrast, expression of GLRX, which promotes the conversion of active reduced glutathione (GSH) into its oxidized form (GSSG), was significantly decreased following melatonin treatment ( Figure 6G )

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