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A 2025 meta-analysis verified that stopping causes a substantial metabolic rebound, with obese patients seeing an average weight gain of 5.63 kg as well as declines in blood pressure, waist circumference, and glycaemic control

A comprehensive assessment addresses these layers rather than assuming the medication alone has failed

The dose titration period is critical: Orforglipron is initiated at a low dose and titrated upward over several weeks, similar to injectable GLP-1 therapies

GIP boosts insulin release but it may also enhance your bodys response to insulin, especially in people with insulin resistance (a key factor in Type 2 diabetes and obesity)