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The Result: You feel physically full for a longer duration after eating, which naturally reduces the frequency of food intake

(39407841) This condition is likely underdiagnosed and underreported due to limited access to diagnostic testing

Novo Nordisks own indirect treatment comparison (the ORION study, presented at Obesity Medicine Association 2026) suggested greater weight loss with oral semaglutide than with orforglipron, though that analysis was industry-funded and drew skepticism from independent researchers

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