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Key Mechanisms of Action: Stimulates Lipolysis (Fat Breakdown) AOD-9604 activates beta-3 adrenergic receptors in adipose (fat) tissue, triggering the release of stored fatty acids for energy use

things like that, said Pisano

For example, a high-fat diet increased the expression of the T1R3 taste receptor in rats, an effect that was reversed by chronic exendin-4 treatment

And so I think thats the big reason that theres so much controversy is that for whatever reason, theres some people who just dont want to look at the older trials that were very long and theyre spending all their time looking at these very short term trials