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Signaling through G-protein pathways (primarily Gs) raises cAMP, engaging PKA/EPAC axes and downstream transcriptional programs relevant to -cell function, gastric motility, and hepatic lipid handling

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4) Future genome-wide association studies should aim to broaden their scope by encompassing diverse ethnic groups and varied patient populations

Enfermedad gastrointestinal severa : Pacientes con gastroparesia u otros trastornos graves de motilidad gastrointestinal no son candidatos ideales para tirzepatida, ya que puede empeorar estos trastornos