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These figures are broadly comparable to those reported with other GLP-1-based therapies such as semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro)
This happens because the body fights to return to its original weight
Growth/differentiation factor-15 (GDF-15) is a stress-induced cytokine expressed in multiple cell types, including cardiomyocytes, adipocytes, and macrophages
There have also been some cases where people with stable skin conditions, such as atopic dermatitis, experienced flare-ups after beginning semaglutide
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