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Previous studies have noted that overexpression of CAT can protect tissues against oxidative insults (Shen et al., 2012

Inhibition of autophagy abrogates TMAO-induced degradation of SERCA2a and attenuates cardiac hypertrophy in vivo Firstly, to further investigate whether autophagy degradation of SERCA2a is involved in TMAO-induced cardiac hypertrophy in vivo, we administered TMAO or vehicle to mice and subsequently injected 3MA intraperitoneally for a duration of 2 weeks prior to sacrifice

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