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Limited data exists for: Understudied Populations: Adults over 75 years (increased sensitivity to appetite suppression) Adolescents (ongoing development considerations) Individuals with BMI under 27 (insufficient safety data) Pregnant or lactating individuals (no safety data) Individuals with significant psychiatric conditions Gender Considerations: Research suggests some metabolic peptides may show differential effects between males and females, though data for cagrilintide and retatrutide specifically remains limited

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(19) Gastric surgeries: If a portion of your stomach has been removed, the body cant produce enough IF, and the amount of space for B12 to be absorbed is also reduced

B12 shots use intramuscular injection, depositing vitamin B12 directly into muscle tissue, typically in the upper arm or thigh