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Mechanistic studies in apoE/ mice reveal that TMAO activates the FXR/SHP axis, specifically repressing Cyp7a1the rate-limiting enzyme in bile acid synthesisthereby blocking classical bile acid synthesis and reducing cholesterol excretion

Dosage and Administration Lambs: 0.5mL at marking or weaning Sheep: 11.5mL pre-lambing Calves: 23mL from 2 months of age Cows: 46mL pre-calving Withholding Periods Meat: Zero (0) days Milk: Zero (0) days Technical Information These documents provide verified product information for safety, handling and regulatory compliance