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In a study on C57BL/6J mice, lifelong supplementation with spermidine led to a significant extension of lifespan, with improvements in mitochondrial function, reduced oxidative stress and enhanced autophagic activity (Reference Eisenberg, Knauer and Schauer22)

"Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences"

Tavares, M