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Mucosal samples from TNBS+ethanol-treated rats indicated a direct correlation between GSH depletion and injury detected as soon as 30 minutes after TNBS+ethanol administration that persisted 24 hours post treatment
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Additionally, many NRF2-regulated metabolic pathways were found to confer growth advantages to cancer cells, such as the upregulation of the PPP, nucleotide synthesis, and NADPH production
The catalytic cysteine is highly susceptible to oxidation and nitrosylation, leading to reversible or irreversible modifications that abolish its nucleophilic function and inactivate its enzyme activity (87, 88)
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