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Mann JFE, Fonseca V, Mosenzon O, et al
This was an unexpected result insofar that GPX3 is considered a classical Nrf2-induced gene and TNF- has repeatedly been reported to upregulate other Nrf2 target genes in various cell types including leukocytes of the myeloid lineage, vascular endothelial cells, and osteoblasts 50,51,52,53,54
The quick answer for busy clinicians If a colleague asks semaglutide or phentermine? in a hallway, the honest one-sentence version is this: reach for semaglutide when you are treating obesity as a chronic disease that needs durable, year-over-year management, and reach for phentermine when you want an inexpensive, fast short-term jump-start for a motivated patient who does not need or cannot afford long-term pharmacotherapy
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