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Additionally, there may be unique benefits for older adults who have difficulty increasing their physical activity due to chronic conditions and health limitations

It also influences insulin sensitivity and glucose metabolism, which are essential factors in weight management, especially for those with obesity-related health issues like type 2 diabetes

Researchers should avoid assuming that a mechanism observed in one tissue necessarily explains all effects in another tissue

Because changes in basal metabolic rate play an important role in body weight homeostasis, energy expenditure (measured by indirect calorimetry) and physical activity (measured by locomotor activity) represent important parameters for gaining further mechanistic insight into anti-obesity drug effects