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Kodym R, Calkins P and Story M
Glucagon-like peptide-1 (GLP-1) receptor agonists and neuroinflammation: Implications for neurodegenerative disease treatment
Early studies in vivo on transport across the BBB revealed that neutral AA moved from blood to brain by facilitative Na + -independent transport by means of a transmembrane transporter known as LAT1 (from system L amino acid transporter) ( slc7a5 gene and forms a heterodimeric complex with the glycoprotein 4F2hc (CD98, SLC3A2) associated by a disulfide bridge
This D-retro-inverso peptide specifically disrupts the FOXO4-p53 protein interaction that maintains senescent cell viability, providing researchers with a sophisticated tool for investigating cellular senescence biology and its role in aging processes
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