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Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation (Conesa et al., 2023)

Ipamorelin is selected when the research question centres on the acute pituitary GH secretory response, receptor selectivity relative to the adrenal axis, or the neuroendocrine architecture of GH pulsatility