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The genetic changes that lead to cancer can happen because of several reasons including errors that occur at cell division, DNA damage that may have been caused by substances in the environment, or genetic predispositions that were inherited from the parents

From an initial pool of 1,455 studies, a total of 1,436 were excluded based on the established criteria: 911 for being off-topic, 233 for lacking in vitro experiments, 134 for being review articles, 95 for not addressing ROS, and 63 for not focusing on the pro-tumorigenic roles of ROS

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