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It belongs to a novel class of agents known as triple agonists , meaning it simultaneously activates three distinct hormone receptors: GIP receptor (glucose-dependent insulinotropic polypeptide) GLP-1 receptor (glucagon-like peptide-1) Glucagon receptor This triple mechanism of action distinguishes retatrutide from currently approved agents such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)

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