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The landmark SURMOUNT-5 trial , published in the New England Journal of Medicine, was the first head-to-head trial comparing the two medications in adults with obesity but without type 2 diabetes
While this is a major victory for Novo Nordisk, manufacturer of Wegovy and Ozempic, the battle to end the compounding of these products isnt over just yet
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MiR-145 expression is dramatically decreased in high glucose-treated RECs, which leads to high glucose-induced oxidative stress and inflammation in RECs by targeted enhancement of toll-like receptor 4 (TLR4) expression and nuclear translocation of NF-B p65 [85]
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