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control or placebo groups was based on their significance in the lives of individuals with PD in accordance with Hammarlund et al., who stated these are the most important outcomes [20]

(2) Bioavailability challenges : Many active ingredients of TCM exhibited suboptimal pharmacokinetic profiles due to structural instability, rapid oxidation, and poor membrane permeability, advanced delivery systems (e.g., lipid-based encapsulation, nanoparticle carriers) can be considered