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Interestingly, a large meta-analysis that explored data from 3181 patients participating in 25 randomized control trials (RCTs) suggested that CPAP promoted significant increase in body weight and BMI in this population [27]

Based on these researches, clinical trials targeting HO-1 should be carried out to evaluate its application in the treatment of DN, so as to provide evidence for clinical application

doi:10.1208/s12248-016-9975-1 182

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