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Lemmens G, Van Camp A, Kourula S, Vanuytsel T, Augustijns P (2021) Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring

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15 Similarly, increased generation of NAD + via the KP in resting, aged or immune-challenged macrophages restores OXPHOS and homeostatic immune responses, whereas inhibition of de novo NAD + synthesis induces an increased inflammation-associated TCA-cycle metabolite succinate and elevated mitochondria-generated ROS, resulting in rising innate immune dysfunction in aging and age-associated diseases