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About half of large employers in the U.S

The most common side effects of amitriptyline include: Dry mouth Blurred vision Constipation Urinary retention Dizziness or lightheadedness Drowsiness or fatigue Weight gain Increased heart rate Tremors Sweating If you experience any severe or persistent side effects while taking amitriptyline, it's essential to contact your healthcare provider immediately

As of 2026, the retatrutide long-term safety data remains incomplete because Phase 3 results have not all been fully peer-reviewed in journal form

That means trying the option with fewer trade-offs first for most people