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Unresolved inflammation can result in sustained and the production of multiple factors that contribute to decreased TJ expression and increased BBB permeability, including interleukin (IL)-1, tumor necrosis factor alpha (TNF-), IL-6, nuclear factor kappa B (NF-B), matrix metalloproteinase (MMP)-9, advanced glycation end-products (AGEs), and reactive oxygen species (ROS) (Hofmann et al., 1999

supplementing them back toward youthful levels is the rationale for long-term use

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Baseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 trial