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[9] [10] These medications work by mimicking incretin hormones, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways
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However, some self-reactive cells escape out into our circulation and are potentially dangerous. Sakaguchi revealed a second mechanism by which self-tolerance arises, showing harmful T-cells can be eliminated by mature T-cells that carry a protein on their surface called CD25
J Diabetes Complicat 26(5):458459
