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They measure each patient's existing 2018 primary-care provider's propensity to adopt GLP-1s by calculating that providers likelihood of prescribing GLP-1s in the 202122 period

Furthermore, participants assigned to tirzepatide had a slower mean rate of decline in estimated glomerular filtration rate over the study period: 1.4 0.2 ml/min/1.73 m 2 body mass per year with tirzepatide compared with 3.6 0.2 ml/min/1.73 m 2 body mass per year with insulin glargine, for a between-group difference of 2.2 ml/min/1.73 m 2 body mass per year [95% CI 1.62.8 ml/min/1.73 m 2 body mass per year] [95]

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These results suggest that GLP-1 secretion depends primarily on Gs-EPAC signals in GLUTag cells