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Cardiotoxicity Two small RCTs: Conflicting results, one showed no effect, one showed reduced cardiac events

The largest meta-analysis of its kind, published in The Lancet, compared 30 antidepressants across 150+ clinical trials (58,000 participants) not for efficacy or tolerability, but for physiological outcomes like weight, blood pressure, heart rate, and metabolism

Overall, the elimination half-life is approximately 13 hours , making it a suitable formulation for once-daily injection

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