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It is approved to reduce major adverse cardiovascular events in adults with established cardiovascular disease and obesity or overweight, to support longterm weight management in adults and adolescents with obesity or adults with overweight plus comorbidities, and to treat noncirrhotic MASH with moderate to advanced fibrosis in adults under an accelerated approval pathway

These side effects are most common after first starting Ozempic or increasing the dose, and they can be managed with diet and lifestyle changes

It is reasonable to hypothesize that retatrutide, like every drug in this class, will require continued use to preserve its effect, but that expectation is an extrapolation from class behavior rather than a demonstrated finding for this specific molecule