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While GLP-1 injections are generally well-tolerated, they can cause side effects in some users

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Exception : Saxagliptin has been associated with an increased risk of hospitalisation for heart failure (SAVOR-TIMI 53 trial), and should be avoided in patients with established HF or high HF risk

In contrast, indicator systems that specifically sense particular redox couples allow real-time observation of redox changes (Gutscher et al., The experimental difficulties to obtain reliable potentials of thiol/disulfide systems prompt further concern to accept these parameters or changes thereof as critical determinants of biological events