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For inducing remission in mild-to-moderate disease , topical (rectal) aminosalicylates are first-line for proctitis and left-sided colitis

This evaluation often includes blood tests, a review of current medications, and an assessment of lifestyle factors

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In the gastrointestinal tract, GLP-1 delays gastric emptying through vagal activation and effects on smooth muscle, increases beta cell proliferation and survival as well as glucose-dependent insulin secretion, suppresses glucagon secretion, and reduces hepatic fat accumulation through fatty acid oxidation as well as hepatic gluconeogenesis [43]